๐Ÿ“„ Paper Digest

2026๋…„ 05์›” 05์ผ (Tue) ยท Europe PMC ยท 2ํŽธ ยท IFโ‰ฅ10 0ํŽธ

Summary

Source

  • Preprint2

Top journals

  • (unspecified)2

Keyword

  • Somatic mosaicism0
  • mosaic0
  • mosaic variant0
  • methylation2
  • PacBio0

๐Ÿ“Œ Pinned

  • ๐Ÿ“Œ Cell0
  • ๐Ÿ“Œ Nature0
  • ๐Ÿ“Œ Science0
Keyword
์ „์ฒด 2Somatic mosaicism0mosaic0mosaic variant0methylation2PacBio0
Source
์ „์ฒดPreprint2

A Systemic Immune-State Axis Distinguishes Psoriatic Arthritis from Psoriasis

Lee YK, Seong H.
Preprint2026-04-27methylation
ํ•œ๊ธ€ ์š”์•ฝ์ „ํ˜ˆ ๋ฉ”ํ‹ธํ™”ยทPBMC scRNAยทํ”ผ๋ถ€ RNAยท์ •์ œ CD ๋ฉด์—ญ์„ธํฌ RNA 4์ข… ๊ณต๊ฐœ ๋ฐ์ดํ„ฐ๋ฅผ ํ†ตํ•ฉ ๋ถ„์„ํ•ด ๊ฑด์„ ๊ณผ ๊ฑด์„ ์„ฑ ๊ด€์ ˆ์—ผ(PsA)์„ ๊ตฌ๋ถ„ํ•˜๋Š” systemic immune-state axis๋ฅผ ๋™์ •ํ–ˆ๋‹ค. PsA๋Š” ๋‹จ์ˆœํ•œ ๊ฑด์„ ์˜ ๊ตญ์†Œ ํ™•์žฅ์ด ์•„๋‹Œ ๋ฉด์—ญ ์ƒํƒœ ์ „ํ™˜์ด ๋™๋ฐ˜๋œ ๋ณ„๊ฐœ ์งˆํ™˜์ž„์„ ์‹œ์‚ฌํ•œ๋‹ค.
10.20944/preprints202604.1871.v1

DNA methylation variability defines a fundamental dimension of tumor epigenomes linked to genomic instability, tumor aggressiveness, and clinical outcomes

Bukovec D, Gjorgjioski B, Misheva MS, et al.
Preprint2026-04-30methylation
ํ•œ๊ธ€ ์š”์•ฝ์•” ์ข…์–‘์—์„œ ํ‰๊ท  ๋ฉ”ํ‹ธํ™” ์ˆ˜์ค€ ์™ธ์— DNA ๋ฉ”ํ‹ธํ™” ๋ณ€๋™์„ฑ(variability)์ด ์ข…์–‘ epigenome์˜ ๋…๋ฆฝ์  ์ฐจ์›์œผ๋กœ ์ž‘์šฉํ•จ์„ ๋Œ€๊ทœ๋ชจ ์ž๋ฃŒ์—์„œ ์ž…์ฆํ–ˆ๋‹ค. ๋ฉ”ํ‹ธํ™” ๊ฐ€๋ณ€์„ฑ์€ ๊ฒŒ๋†ˆ ๋ถˆ์•ˆ์ •์„ฑยท์ข…์–‘ ๊ณต๊ฒฉ์„ฑยท์ž„์ƒ ๊ฒฐ๊ณผ์™€ ์—ฐ๊ด€๋˜์–ด ์ƒˆ๋กœ์šด ์˜ˆํ›„ ๋ฐ”์ด์˜ค๋งˆ์ปค๊ฐ€ ๋  ์ˆ˜ ์žˆ๋‹ค.
10.21203/rs.3.rs-9393929/v1